The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) The integrins are cell membrane receptors composed of alpha and beta subunits. There are about 18 alpha subunits and 8 beta subunits.Integrins alpha6 and beta 4 heterodimerises to form the active receptor complex. Alpha6Beta4 are mainly involved with hemidesmosomes formation, cell adhesion and cell attachments. Many cytoskeletal proteins like keratins and Bullous pemphigoid antigen (BPAG) are associated with Alpha6beta4.They also associate with other receptors like Epidermal Growth factor receptor(EGFR), macrophage stimulating factor receptors. The vital ligands are Laminins, Kalinins. Various kinases (like MEKs, ERKs, PKCs, YES, FYN) and adapter molecules like (GRBs) are involved in this pathway. Alpha6beta4 modulate processes as diverse as cell proliferation, differentiation, apoptosis, migration and tissue morphogenesis. Homo sapiens 9606 taxon Alpha6Beta4Integrin CPATH 1 proteolytic cleavage reaction MI:0194 PSIMI 9344615 Pubmed NOT-SPONTANEOUS plasma membrane GO 0005886 proteolytic cleavage site IOB IOB:05 in vitro MI:0492 PSIMI 9344615 Pubmed Proteolytic Cleavage CPATH 15 ITGB4 Homo sapiens 9606 taxon Pubmed 12441134 GP150 NP_000204 refseq Pubmed 2311577 CD104 antigen OMIM 147557 Gene ITGB4 ITGB4 Integrin beta 4 HPRD 00946 11684709 Pubmed MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPTAPRTTAARAGRAAAVPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT AFFYMETRIX Hs.85266.0.S1_3p_a_at AFFYMETRIX Hs.85266.3.S1_3p_x_at AFFYMETRIX 204989_s_at AFFYMETRIX 230704_s_at AFFYMETRIX g2293520_3p_a_at AFFYMETRIX 214292_at AFFYMETRIX g4504768_3p_a_at AFFYMETRIX 204990_s_at AFFYMETRIX 406_at AFFYMETRIX 38746_at AFFYMETRIX 211905_s_at AFFYMETRIX Hs.85266.3.S1_3p_at AFFYMETRIX Hs.85266.2.A1_3p_at CPATH 100 Molecular association of ITGB4 and CLCA1.ITGB4 can bind bind to unprocessed 125kDa and processed 35kDa CLCA1, but not to the processed 90kDa CLCA1 protein. The binding motif for ITGB4 is not conserved in the human CLCA1. Pubmed 14512419 direct interaction PSIMI MI:0407 ITGB4-CLCA1 Pubmed 12110680 ITGB4-CLCA1 plasma membrane GO 0005886 in vitro MI:0492 PSIMI in vivo PSIMI MI:0493 0008372 GO cellular component unknown CPATH 62 CaCC CLCA1 CLCA1 Homo sapiens 9606 taxon Pubmed 14512419 Calcium activated chloride channel 1 HPRD 04880 Pubmed 12110680 CLCA1 refseq NP_001276 Pubmed 9828122 MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLFEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGKAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQSELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTTQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA OMIM 603906 Gene AFFYMETRIX g4585468_3p_at AFFYMETRIX 210107_at AFFYMETRIX 38884_at CPATH 139 CY-NU-SMAD3 GO 0005737 cytoplasm Transport of SMAD3 from cytoplasm to nucleus. Alpha6beta4 does not inhibit TGFbeta-mediated Smad3 phosphorylation but prevents translocation of phosphoSmad2 to the nucleus. 12902406 Pubmed GO 0005634 nucleus in vitro MI:0492 PSIMI CPATH 79 MADH3 SMA and MAD related protein 3 Pubmed 10846168 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRS LDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLV PRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPN PMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRN AAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAA LLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR CSSVS Pubmed 11058129 NP_005893 refseq HPRD 04380 JV15-2 HsT17436 Homo sapiens 9606 taxon SMAD3 SMAD3 MADH3 AFFYMETRIX 38944_at AFFYMETRIX 205396_at AFFYMETRIX 205398_s_at AFFYMETRIX g5174512_3p_s_at AFFYMETRIX 1433_g_at AFFYMETRIX 205397_x_at AFFYMETRIX 1950_s_at AFFYMETRIX g1673576_3p_s_at AFFYMETRIX 1454_at CPATH 143 Interaction between ITGB4 and 14-3-3 tau Pubmed 12919677 GO 0005737 cytoplasm in vitro MI:0492 PSIMI in vivo PSIMI MI:0493 MI:0018 PSIMI two hybrid ITGB4-YWHAQ plasma membrane GO 0005886 ITGB4-YWHAQ direct interaction PSIMI MI:0407 CPATH 30 YWHAQ MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN Pubmed 12919677 1C5 00886 HPRD Homo sapiens 9606 taxon 14-3-3 protein tau HS1 14-3-3 tau YWHAQ NP_006817 refseq 14-3-3 tau Gene OMIM 609009 Tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide Pubmed 11864996 AFFYMETRIX 212426_s_at AFFYMETRIX Hs.74405.2.A1_3p_a_at AFFYMETRIX 213699_s_at AFFYMETRIX 200693_at AFFYMETRIX g5803226_3p_a_at AFFYMETRIX 32530_at AFFYMETRIX 409_at CPATH 134 11331299 Pubmed PHYSIOL-LEFT-TO-RIGHT Phosphorylation of ERBB2 by ERBB2. in vivo PSIMI MI:0493 GO 0005737 cytoplasm AP-ERBB2-ERBB2 CPATH 43 NGL Homo sapiens 9606 taxon ERBB2 OMIM Gene 164870 ERBB2 ErbB2 refseq NP_004439 ERBB2 TKR1 HPRD 01281 MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIVSAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERAKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV 9344587 Pubmed Pubmed 14730713 NEU HER2 11331299 Pubmed AFFYMETRIX 234354_x_at AFFYMETRIX 33218_at AFFYMETRIX Hs.241524.0.S1_3p_at AFFYMETRIX g10181232_3p_a_at AFFYMETRIX g10181232_3p_at AFFYMETRIX 1901_s_at AFFYMETRIX 216836_s_at AFFYMETRIX g10181232_3p_x_at AFFYMETRIX Hs.323910.2.A1_3p_a_at AFFYMETRIX 210930_s_at AFFYMETRIX 210930_3p_s_at AFFYMETRIX 1802_s_at CPATH 99 phosphorylation reaction PSIMI MI:0217 11331299 Pubmed Phosphorylation NOT-SPONTANEOUS in vivo PSIMI MI:0493 GO 0005737 cytoplasm PSIMI MI:0170 phosphorylation site CPATH 44 Phosphorylation of ITGA6 by PRKCD.PMID 12919677 states human ITGA6 and PRKCD. Exp-vtPMID 11389095 states about mouse ITGA6. Exp-- vv, vt. Host orgn- MouseITGA6 is phosphorylated at Serine residues Pubmed 12919677 in vitro MI:0492 PSIMI in vivo PSIMI MI:0493 GO 0005737 cytoplasm Pubmed 11389095 P-PRKCD-ITGA6 PHYSIOL-LEFT-TO-RIGHT CPATH 16 Phosphorylation NOT-SPONTANEOUS phosphorylation reaction PSIMI MI:0217 plasma membrane GO 0005886 Pubmed 11389095 Pubmed 12919677 PSIMI MI:0170 phosphorylation site CPATH 17 CD49f MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRGEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPYLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRNKKDHYDATYHKAEIHAQPSDKERLTSDA VLA-6 HPRD 00945 7721947 Pubmed OMIM 147556 Gene Homo sapiens 9606 taxon ITGA6 ITGA6 refseq NP_000201 Pubmed 2070796 ITGA6 AFFYMETRIX 215177_s_at AFFYMETRIX Hs.227730.2.A1_3p_a_at AFFYMETRIX 2077_at AFFYMETRIX 229643_at AFFYMETRIX Hs.227730.1.S1_3p_at AFFYMETRIX 33411_g_at AFFYMETRIX g4557674_3p_at AFFYMETRIX 201656_at AFFYMETRIX 41266_at AFFYMETRIX 33410_at CPATH 88 HPRD 01501 PRKCD PKC delta Pubmed 12919677 PRKCD 11571229 Pubmed Homo sapiens 9606 taxon Protein kinase C delta NP_006245 refseq MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED 176977 OMIM Gene PRKCD AFFYMETRIX 202545_at AFFYMETRIX 1810_s_at AFFYMETRIX 32046_at AFFYMETRIX g5453969_3p_at CPATH 124 NOT-SPONTANEOUS in vitro MI:0492 PSIMI Pubmed 12110680 925 EQUAL PSIMI MI:0170 phosphorylation site GO 0005737 cytoplasm Phosphorylation phosphorylation reaction PSIMI MI:0217 CPATH 31 Focal adhesion kinase 1 PTK2 OMIM Gene 600758 10801330 Pubmed Homo sapiens 9606 taxon MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH PTK2 Focal adhesion kinase Protein tyrosine kinase 2 FAK1 02859 HPRD FADK 1 Pubmed 12110680 NP_722560 refseq FAK FAK pp125FAK AFFYMETRIX Hs.156059.0.A1_3p_at AFFYMETRIX Hs.126421.0.A1_3p_x_at AFFYMETRIX Hs.740.1.S2_3p_x_at AFFYMETRIX 239121_at AFFYMETRIX Hs.740.1.S2_3p_at AFFYMETRIX g5032000_3p_a_at AFFYMETRIX 241453_at AFFYMETRIX 208820_at AFFYMETRIX 1559529_at AFFYMETRIX Hs.126421.0.A1_3p_at AFFYMETRIX 36117_at AFFYMETRIX Hs2.436335.1.S1_3p_at AFFYMETRIX 207821_s_at CPATH 89 Interaction between Alpha6beta4 and EGFR GO 0005737 cytoplasm Alpha6beta4-EGFR in vivo PSIMI MI:0493 11684709 Pubmed direct interaction PSIMI MI:0407 Alpha6beta4-EGFR CPATH 48 HPRD 01323 Pubmed 10648558 RHOA RHO12 RHOA Ras homolog gene family member A refseq NP_001655 12466390 Pubmed Aplysia ras related homolog 12 RHOA ARH12 Oncogene rho H12 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLR PLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVK PEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL Transforming protein RhoA Homo sapiens 9606 taxon ARHA RHOH12 AFFYMETRIX 200059_s_at AFFYMETRIX 1555814_a_at AFFYMETRIX 1394_at AFFYMETRIX Hs2.77273.2.S1_3p_s_at AFFYMETRIX 37309_at CPATH 122 Rhotekin OMIM Gene 602288 Pubmed 10648558 RTKN RTKN Rhotekin 10940294 Pubmed AAH04558 genbank HPRD 03795 Homo sapiens 9606 taxon MFSRNHRSRVTVARGSALEMEFKRGRFRLSLFSDLPEDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILSYMGELQRRKEAQVLGKTSRRPSDSGPPAERSPCRGRVCISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQLGEHIQDTEMILVDRTLTDISFQSNVLFAEAGPDFELRLELYGACVEEEGALTGGPKRLATKLSSSLGRSSGRRVRASLDSAGGSGSSPILLPTPVVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLASHEENPAWLPLYGSVCCRLAAQPLCMTQPTASGTLRVQQAGEMQNWAQVHGVLKGTNLFCYRQPEDADTGEEPLLTIAVNKETRVRAGELDQALGRPFTLSISNQYGDDEVTHTLQTESREALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQALAKQGSLYHEMAIEPLDDIAAVTDILTQREGARLETPPPWLAMFTDQPALPNPCSPASVAPAPDWTHPLPWGRPRTFSLDAVPPDHSPRARSVAPLPPQRSPRTRGLCSKGQPRTWLQSPV CPATH 127 BPAG2-BPAG1 direct interaction PSIMI MI:0407 10637308 Pubmed plasma membrane GO 0005886 Pubmed 12482924 MI:0018 PSIMI two hybrid in vivo PSIMI MI:0493 Interaction between BPAG2 and BPAG1 10637308 Pubmed BPAG2-BPAG1 CPATH 80 BP180 BPAG2 Collagen, type XVII, alpha-1 COL17A1 Bullous pemphigoid antigen 2 00223 HPRD COL17A1 MDVTKKNKRDGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTASLGGGSRLEKQSLTHGSSGYINSTGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKTHVTRHAYEGSSSGNSSPEYPRKEFASSSTRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASVSPTRNSSNTLPIPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTTQSSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLSTSSSVFGMQNNLAPSLTTLSHGTTTTSTAYGVKKNMPQSPAAVNTGVSTSAACTTSVQSDDLLHKDCKFLILEKDNTPAKKEMELLIMTKDSGKVFTASPASIAATSFSEDTLKKEKQAAYNADSGLKAEANGDLKTVSTKGKTTTADIHSYSSSGGGGSGGGGGVGGAGGGPWGPAPAWCPCGSCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRKLKARVDELERIRRSILPYGDSMDRIEKDRLQGMAPAAGADLDKIGLHSDSQEELWMFVRKKLMMEQENGNLRGSPGPKGDMGSPGPKGDRGFPGTPGIPGPLGHPGPQGPKGQKGSVGDPGMEGPMGQRGREGPMGPRGEAGPPGSGEKGERGAAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPGPVGLQGLRGEVGLPGVKGDKGPMGPPGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKGAMGPAGPDGHQGPRGEQGLTGMPGIRGPPGPSGDPGKPGLTGPQGPQGLPGTPGRPGIKGEPGAPGKIVTSEGSSMLTVPGPPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSIPGPPGPRGPPGEGLPGPPGPPGSFLSNSETFLFGPPGPPGPPGPKGDQGPPGPRGHQGEQGLPGFSTSGSSSFGLNLQGPPGPPGPQGPKGDKGDPGVPGALGIPSGPSEGGSSSTMYVSGPPGPPGPPGPPGSISSSGQEIQQYISEYMQSDSIRSYLSGVQGPPGPPGPPGPVTTITGETFDYSELASHVVSYLRTSGYGVSLFSSSISSEDILAVLQRDDVRQYLRQYLMGPRGPPGPPGASGDGSLLSLDYAELSSRILSYMSSSGISIGLPGPPGPPGLPGTSYEELLSLLRGSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSYLHTAGLSFIPGPPGPPGPPGPRGPPGVSGALATYAAENSDSFRSELISYLTSPDVRSFIVGPPGPPGPQGPPGDSRLLSTDASHSRGSSSSSHSSSVRRGSSYSSSMSTGGGGAGSLGAGGAFGEAAGDRGPYGTDIGPGGGYGAAAEGGMYAGNGGLLGADFAGDLDYNELAVRVSESMQRQGLLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTADLMDFFQTYGAIQGPPGQKGEMGTPGPKGDRGPAGPPGHPGPPGPRGHKGEKGDKGDQVYAGRRRRRSIAVKP Alpha 1 type XVII collagen Pubmed 12482924 10637308 Pubmed 113811 OMIM Gene 11514543 Pubmed refseq NP_000485 BPAG2 Homo sapiens 9606 taxon AFFYMETRIX g4502942_3p_at AFFYMETRIX 41618_at AFFYMETRIX 204636_at CPATH 106 BP240 BPAG1 Pubmed 11323216 Pubmed 2579167 Homo sapiens 9606 taxon BPAG1 OMIM Gene 113810 00222 HPRD DMH MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSK CATX15 Dystonia musculorum protein BPAG1 2645368 Pubmed Dystonin Pubmed 12482924 BPA Pubmed 14517317 MACF2 3880796 Pubmed Trabeculin-beta refseq NP_899236 AFFYMETRIX 232098_at AFFYMETRIX 32780_at AFFYMETRIX Hs.620.1.S1_3p_a_at AFFYMETRIX 212253_x_at AFFYMETRIX 32781_f_at AFFYMETRIX 216918_s_at AFFYMETRIX Hs2.198689.2.S1_3p_at AFFYMETRIX 220154_at AFFYMETRIX Hs.287669.0.S1_3p_at AFFYMETRIX Hs.198689.0.S1_3p_a_at AFFYMETRIX g9966862_3p_at AFFYMETRIX 40304_at AFFYMETRIX g4502442_3p_at AFFYMETRIX 215016_x_at AFFYMETRIX 1553191_at AFFYMETRIX 204455_at AFFYMETRIX 32782_r_at AFFYMETRIX 212254_s_at AFFYMETRIX Hs.198689.0.S2_3p_a_at CPATH 101 11438664 Pubmed PI3K-IRS2 PI3K-IRS2 plasma membrane GO 0005886 in vivo PSIMI MI:0493 in vitro MI:0492 PSIMI Interaction of PI3K with IRS2:IRS proteins contain several PI3K binding sites, and involved in the activation of PI3K. direct interaction PSIMI MI:0407 CPATH 86 P-PIK3R1-AKT1 PHYSIOL-LEFT-TO-RIGHT 10527852 Pubmed in vitro MI:0492 PSIMI Phosphorylation of AKT1 by PIK3R1. plasma membrane GO 0005886 CPATH 59 Phosphorylation phosphorylation reaction PSIMI MI:0217 GO 0005737 cytoplasm 10527852 Pubmed in vitro MI:0492 PSIMI PSIMI MI:0170 phosphorylation site NOT-SPONTANEOUS CPATH 60 AKT1 RAC-alpha serine/threonine protein kinase PRKBA Gene OMIM 164730 Protein kinase B MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASSTA AKT1 01261 HPRD PKB NP_005154 refseq AKT1 C-AKT RAC-PK-alpha RAC Homo sapiens 9606 taxon Pubmed 9395488 AFFYMETRIX 1564_at AFFYMETRIX g4885060_3p_a_at AFFYMETRIX 207163_s_at CPATH 107 11331299 Pubmed genbank P27986 01381 HPRD Phosphatidyl inositol 3 kinase associated p85 alpha Phosphatidyl inositol 3 kinase regulatory 85 KD, alpha p85 alpha Phosphatidylinositol 3 kinase regulatory subunit, alpha PIK3R1 OMIM Gene 171833 PIK3R1 MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQNAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 11752634 Pubmed GRB1 Homo sapiens 9606 taxon PIK3R1 CPATH 91 in vitro MI:0492 PSIMI Pubmed 11375975 MI:0018 PSIMI two hybrid BPAG1-ERBIN Pubmed 11375975 plasma membrane GO 0005886 BPAG1-ERBIN direct interaction PSIMI MI:0407 Interaction between BPAG1 and ERBIN. CPATH 32 ERBIN 06090 HPRD genbank AAK69431 Densin 180 like protein 606944 OMIM Gene Homo sapiens 9606 taxon Erbb2 interacting protein ERBIN MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKCPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS ERBIN Pubmed 11375975 Pubmed 11279080 ERBB2IP CPATH 123 Pubmed 10477766 NOT-SPONTANEOUS Phosphorylation PSIMI MI:0170 phosphorylation site plasma membrane GO 0005886 phosphorylation reaction PSIMI MI:0217 Pubmed 12919677 15121854 Pubmed CPATH 34 MST1R-YWHAQ MI:0018 PSIMI two hybrid in vitro MI:0492 PSIMI Pubmed 12919677 in vivo PSIMI MI:0493 direct interaction PSIMI MI:0407 Interaction between MST1R and 14-3-3 tau plasma membrane GO 0005886 GO 0005737 cytoplasm MST1R-YWHAQ CPATH 73 Pubmed 12919677 MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAGSFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLQVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIRGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT Homo sapiens 9606 taxon Gene OMIM 600168 refseq NP_002438 Macrophage stimulating protein receptor RON MST1R Ron protein tyrosine kinase CDw136 Pubmed 7939629 MST1R MST1R MSP receptor HPRD 02545 Macrophage stimulating 1 receptor AFFYMETRIX g4505264_3p_at AFFYMETRIX 205455_at AFFYMETRIX g4505264_3p_x_at AFFYMETRIX 1317_at CPATH 115 9856810 Pubmed plasma membrane GO 0005886 ITGA6-BPAG2 ITGA6-BPAG2 7790367 Pubmed in vitro MI:0492 PSIMI 7790367 Pubmed Interaction between ITGA6 and BPAG2 direct interaction PSIMI MI:0407 CPATH 41 Interaction between SHC and GRB2 GO 0005737 cytoplasm SHC1-GRB2 SHC1-GRB2 9171350 Pubmed in vitro MI:0492 PSIMI direct interaction PSIMI MI:0407 CPATH 70 SHC1 SHCA SHC1 p66 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL NP_892113 refseq SHC1 9171350 Pubmed 10971656 Pubmed SHC (Src homology 2 domain containing) transforming protein 1 OMIM 600560 Gene HPRD 02780 p52 Homo sapiens 9606 taxon SHC p46 AFFYMETRIX 31445_at AFFYMETRIX 217048_at AFFYMETRIX 201469_s_at AFFYMETRIX Hs.81972.0.A1_3p_a_at AFFYMETRIX Hs.81972.1.A1_3p_a_at AFFYMETRIX 38118_at AFFYMETRIX Hs.166089.0.S1_3p_at AFFYMETRIX 214853_s_at CPATH 111 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 9171350 Pubmed Growth factor receptor bound protein 2 OMIM Gene 108355 Abundant Src homology protein NP_002077 refseq Homo sapiens 9606 taxon Pubmed 10051406 GRB2 GRB2 GRB2 00150 HPRD ASH AFFYMETRIX 215075_s_at AFFYMETRIX 223049_at AFFYMETRIX 1565_s_at AFFYMETRIX Hs.296381.1.A1_3p_a_at AFFYMETRIX Hs.6289.1.A1_3p_at AFFYMETRIX 228572_at AFFYMETRIX g12005510_3p_at AFFYMETRIX 33855_at CPATH 110 GO 0005634 nucleus 9374518 Pubmed CY-NU-ITGB4BP Translocation of ITGB4BP from cytoplasm to nucleus. in vitro MI:0492 PSIMI GO 0005737 cytoplasm CPATH 85 ITGB4BP ITGB4BP p27BBP HPRD 04221 Homo sapiens 9606 taxon ITGB4BP 9374518 Pubmed refseq NP_002203 MAVRASFENNCEIGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGL LVPNNTTDQELQHIRNSLPDTVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQ TVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDT TSTELSVVESVFKLNEAQPSTIATSMRDSLIDSLT p27 beta 4 binding protein B4 integrin interactor EIF3A EIF6 CAB Eukaryotic translation initiation factor 6 Eukaryotic translation initiation factor 3A AFFYMETRIX 210213_s_at AFFYMETRIX g2809382_3p_a_at AFFYMETRIX 35262_at CPATH 126 GO 0005737 cytoplasm Pc-MMP7-ITGB4 9344615 Pubmed Proteolytic Cleavage of ITGB4 by MMP7. PHYSIOL-LEFT-TO-RIGHT in vitro MI:0492 PSIMI CPATH 61 MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK refseq NP_002414 Matrilysin, Uterine Homo sapiens 9606 taxon 9344615 Pubmed Matrix metalloproteinase 7 MMP7 OMIM Gene 178990 Matrin 01525 HPRD MMP7 Putative metalloproteinase I MMP7 PUMP1 AFFYMETRIX g13027804_3p_at AFFYMETRIX 668_s_at AFFYMETRIX 204259_at CPATH 138 Pubmed 12919677 P-AKT1-MST1R in vitro MI:0492 PSIMI Phosphorylation of MST1R by AKT1.MST1R S1394 phosphorylation is induced by MSP through a receptor mediated PI3K and Akt activation.pubmed : 12919677 GO 0005737 cytoplasm PHYSIOL-LEFT-TO-RIGHT CPATH 29 phosphorylation reaction PSIMI MI:0217 plasma membrane GO 0005886 Pubmed 12919677 Phosphorylation 1394 EQUAL PSIMI MI:0170 phosphorylation site in vitro MI:0492 PSIMI NOT-SPONTANEOUS CPATH 10 ITGB4-ERBIN direct interaction PSIMI MI:0407 Pubmed 11375975 plasma membrane GO 0005886 MI:0018 PSIMI two hybrid in vitro MI:0492 PSIMI Interaction between ITGB4 and ERBIN. ITGB4-ERBIN CPATH 14 EGFR-AR EGFR-AR Interaction between EGFR and AR in vivo PSIMI MI:0493 Pubmed 12534934 direct interaction PSIMI MI:0407 GO 0005634 nucleus plasma membrane GO 0005886 CPATH 83 MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ SBMA Gene OMIM 313700 NR3C4 Homo sapiens 9606 taxon 02437 HPRD SMAX1 DHTR Pubmed 11795379 AR Pubmed 12534934 Dihydrotestosterone receptor KD HUMARA 11396657 Pubmed AIS AR NP_000035 refseq AR TFM AFFYMETRIX 1577_at AFFYMETRIX g178655_3p_at AFFYMETRIX g5639998_3p_s_at AFFYMETRIX 211110_s_at AFFYMETRIX 1578_g_at AFFYMETRIX 211621_at CPATH 103 HER1 7640657 Pubmed 00579 HPRD 11684709 Pubmed EGFR Homo sapiens 9606 taxon MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA EGF receptor 131550 Gene OMIM refseq NP_005219 EGFR ERBB1 EGFR Epidermal growth factor receptor AFFYMETRIX 201983_s_at AFFYMETRIX 37327_at AFFYMETRIX 1537_at AFFYMETRIX Hs2.367845.1.S1_3p_at AFFYMETRIX Hs2.367845.1.S1_3p_x_at AFFYMETRIX 211551_at AFFYMETRIX g1628549_3p_s_at AFFYMETRIX Hs.77432.0.S1_3p_a_at AFFYMETRIX 1565483_at AFFYMETRIX 211607_x_at AFFYMETRIX 211550_at AFFYMETRIX g12002211_3p_at AFFYMETRIX g181984_3p_at AFFYMETRIX 210984_x_at AFFYMETRIX 201984_s_at AFFYMETRIX g4885198_3p_a_at AFFYMETRIX 1565484_x_at CPATH 144 plasma membrane GO 0005886 MST1R-YWHAZ MI:0018 PSIMI two hybrid in vitro MI:0492 PSIMI Pubmed 12919677 in vivo PSIMI MI:0493 direct interaction PSIMI MI:0407 Interaction between MST1R and 14-3-3-zeta GO 0005737 cytoplasm MST1R-YWHAZ CPATH 47 14-3-3-zeta Pubmed 12919677 Brain protein 14-3-3, zeta isoform YWHAZ refseq NP_003397 14-3-3-zeta MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, zeta isoform Homo sapiens 9606 taxon OMIM Gene 601288 8037685 Pubmed 03183 HPRD YWHAZ AFFYMETRIX 36760_at AFFYMETRIX g13177678_3p_a_at AFFYMETRIX g4507952_3p_a_at AFFYMETRIX g899458_3p_a_at AFFYMETRIX Hs.71848.0.S1_3p_at AFFYMETRIX 214848_at AFFYMETRIX 1235_at AFFYMETRIX 34642_at AFFYMETRIX 200639_s_at AFFYMETRIX 200640_at AFFYMETRIX 200641_s_at AFFYMETRIX 200638_s_at CPATH 131 Pubmed 12441134 Molecular Association between ITGB4 and VIM.Takes place at cell membrane. ITGB4-VIM plasma membrane GO 0005886 ITGB4-VIM in vivo PSIMI MI:0493 GO 0005737 cytoplasm direct interaction PSIMI MI:0407 CPATH 68 VIM VIM Pubmed 11911279 Pubmed 12441134 VIM MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTFLIKTVETRDGQVINETSQHHDDLE HPRD 01899 193060 OMIM Gene Vimentin Homo sapiens 9606 taxon NP_003371 refseq AFFYMETRIX Hs2.375145.1.A1_3p_at AFFYMETRIX Hs2.375145.1.A1_3p_x_at AFFYMETRIX 201426_s_at AFFYMETRIX 1555938_x_at AFFYMETRIX 34091_s_at AFFYMETRIX Hs.297753.0.A1_3p_a_at CPATH 120 plasma membrane GO 0005886 Pubmed 12482924 Interaction between ITGB4 and BPAG2. ITGB4-BPAG2 9087447 Pubmed in vivo PSIMI MI:0493 in vitro MI:0492 PSIMI 9660880 Pubmed 9500991 Pubmed 9660880 Pubmed direct interaction PSIMI MI:0407 ITGB4-BPAG2 CPATH 82 NOT-SPONTANEOUS Phosphorylation GO 0005737 cytoplasm phosphorylation reaction PSIMI MI:0217 12105188 Pubmed in vivo PSIMI MI:0493 EQUAL 65 PSIMI MI:0170 phosphorylation site CPATH 58 4EBP1 11114166 Pubmed 602223 Gene OMIM 4EBP1 refseq NP_004086 EIF4EBP1 PHAS1 Eukaryotic translation initiation factor 4E binding protein 1 12105188 Pubmed 03746 HPRD EIF 4E binding protein 1 MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI Homo sapiens 9606 taxon EIF4EBP1 AFFYMETRIX 373_at AFFYMETRIX 221539_at AFFYMETRIX g11527778_3p_at AFFYMETRIX 31597_r_at CPATH 114 Interaction between Alpha6Beta4 and Laminin11 plasma membrane GO 0005886 Alpha6Beta4-Laminin11 in vitro MI:0492 PSIMI Pubmed 10671376 direct interaction PSIMI MI:0407 Alpha6Beta4-Laminin11 CPATH 75 9602068 Pubmed CD151 Pubmed 10811835 SFA1 Gene 602243 OMIM Platelet surface glycoprotein gp27 MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY Homo sapiens 9606 taxon Pubmed 8627808 PETA3 9111230 Pubmed refseq NP_004348 GP27 HPRD 03763 CD151 CD151 AFFYMETRIX g4757941_3p_a_at AFFYMETRIX 36644_at AFFYMETRIX 204306_s_at CPATH 119 Pubmed 12919677 in vitro MI:0492 PSIMI MI:0018 PSIMI two hybrid ITGB4-YWHAB direct interaction PSIMI MI:0407 ITGB4-YWHAB GO 0005737 cytoplasm plasma membrane GO 0005886 Interaction between ITGB4 and 14-3-3-beta CPATH 63 Protein kinase C inhibitor protein-1 Homo sapiens 9606 taxon Brain protein 14-3-3, beta isoform 14-3-3-beta GW128 Protein 1054 YWHAB NP_003395 refseq 14-3-3 protein beta/alpha 8037685 Pubmed MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN HPRD 03184 14-3-3-beta Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HS1 KCIP-1 OMIM Gene 601289 Pubmed 12919677 YWHAB AFFYMETRIX 208743_s_at AFFYMETRIX 217717_s_at AFFYMETRIX 217718_s_at AFFYMETRIX 32324_at AFFYMETRIX g12655022_3p_a_at AFFYMETRIX g12655022_3p_s_at AFFYMETRIX g7661715_3p_a_at AFFYMETRIX Hs.182238.0.A1_3p_a_at CPATH 142 plasma membrane GO 0005886 ITGB4-YES 11684709 Pubmed Interaction between Beta4 and YES ITGB4-YES direct interaction PSIMI MI:0407 GO 0005737 cytoplasm in vivo PSIMI MI:0493 CPATH 18 NP_005424 refseq 164880 OMIM Gene YES1 YES HPRD 01285 c-Yes Homo sapiens 9606 taxon 11684709 Pubmed YES MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL Pubmed 2067846 Yamaguchi sarcoma oncogene YES1 AFFYMETRIX 202933_s_at AFFYMETRIX 210917_at AFFYMETRIX 1674_at AFFYMETRIX g4885660_3p_a_at AFFYMETRIX 202932_at AFFYMETRIX g7770264_RC_3p_at CPATH 125 Interaction between ITGB4 and MET.1)Following Met activation, alpha6beta4 is tyrosine phosphorylated and combines with Shc and PI3K, generating an additional signaling platform that potentiates HGF-triggered activation of Ras- and PI3K-dependent pathways. Pubmed 11733063 plasma membrane GO 0005886 MET-ITGB4 in vivo PSIMI MI:0493 Pubmed 14602071 Pubmed 14602071 direct interaction PSIMI MI:0407 MET-ITGB4 CPATH 3 MET MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS MET NP_000236 refseq Homo sapiens 9606 taxon HGFR Hepatocyte growth factor receptor RCCP2 Pubmed 11733063 01280 HPRD Renal cell carcinoma, papillary, 2 gene MET OMIM Gene 164860 Pubmed 2819873 AFFYMETRIX g625085_3p_s_at AFFYMETRIX 213816_s_at AFFYMETRIX Hs.285754.1.S1_3p_a_at AFFYMETRIX Hs.285754.1.S2_3p_at AFFYMETRIX 213807_x_at AFFYMETRIX Hs.285754.0.S2_3p_at AFFYMETRIX 203510_at AFFYMETRIX 35684_at AFFYMETRIX 211599_x_at CPATH 105 plasma membrane GO 0005886 direct interaction PSIMI MI:0407 Alpha6Beta4-Laminin4 Interaction between Alpha6Beta4 and Laminin4 in vivo PSIMI MI:0493 7721947 Pubmed in vitro MI:0492 PSIMI Alpha6Beta4-Laminin4 0008372 GO cellular component unknown CPATH 66 OMIM 604003 Gene MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISNIKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAHGDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNNDKPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASIMFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPPTFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEIRAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTSGDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAFSRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIILFDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNSAVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDGAGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGNIQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL HPRD 04923 Pubmed 10362588 Homo sapiens 9606 taxon Pubmed 14512419 Calcium activated chloride channel 2 CLCA2 refseq NP_006527 CLCA2 CLCA2 Pubmed 12110680 AFFYMETRIX 206166_s_at AFFYMETRIX g5138899_3p_a_at AFFYMETRIX Hs.72365.0.A1_3p_at AFFYMETRIX 206164_at AFFYMETRIX 217528_3p_at AFFYMETRIX 217528_at AFFYMETRIX 40356_at AFFYMETRIX g12025665_3p_s_at AFFYMETRIX 206165_s_at CPATH 112 Pubmed 12919677 in vivo PSIMI MI:0493 in vitro MI:0492 PSIMI MI:0018 PSIMI two hybrid GO 0005737 cytoplasm direct interaction PSIMI MI:0407 MST1R-YWHAB Interaction between MST1R and 14-3-3-beta MST1R-YWHAB plasma membrane GO 0005886 CPATH 81 in vivo PSIMI MI:0493 11684709 Pubmed plasma membrane GO 0005886 Phosphorylation PSIMI MI:0170 phosphorylation site NOT-SPONTANEOUS phosphorylation reaction PSIMI MI:0217 CPATH 12 Interaction between ITGB4 and BPAG1.Dystonin-ABD domain interacts with ITGB4. plasma membrane GO 0005886 Pubmed 12482924 in vivo PSIMI MI:0493 MI:0018 PSIMI two hybrid Pubmed 14517317 direct interaction PSIMI MI:0407 ITGB4-BPAG1 ITGB4-BPAG1 CPATH 27 plasma membrane GO 0005886 ITGB4-PI3K Pubmed 11733063 in vitro MI:0492 PSIMI ITGB4-PI3K Interaction between ITGB4 and PI3K direct interaction PSIMI MI:0407 CPATH 64 ERBB2-ITGB4 ERBB2-ITGB4 10744756 Pubmed in vivo PSIMI MI:0493 direct interaction PSIMI MI:0407 GO 0005737 cytoplasm plasma membrane GO 0005886 Interaction between ERBB2 and ITGB4 10744756 Pubmed CPATH 2 plasma membrane GO 0005886 Interaction between Alpha6Beta4 and Laminin2 7721947 Pubmed direct interaction PSIMI MI:0407 Alpha6Beta4-Laminin2 Alpha6Beta4-Laminin2 in vitro MI:0492 PSIMI in vivo PSIMI MI:0493 GO 0005737 cytoplasm CPATH 13 Phosphorylation of BAD by AKT1. GO 0005737 cytoplasm 10527852 Pubmed in vitro MI:0492 PSIMI P-AKT1-BAD PHYSIOL-LEFT-TO-RIGHT CPATH 77 PSIMI MI:0170 phosphorylation site 0008372 GO cellular component unknown phosphorylation reaction PSIMI MI:0217 10527852 Pubmed in vitro MI:0492 PSIMI Phosphorylation NOT-SPONTANEOUS CPATH 7 HPRD 04409 10527852 Pubmed BAD Homo sapiens 9606 taxon BCL2L8 10949026 Pubmed NP_004313 refseq Bcl-XL/Bcl-2 associated death promoter BCL2 binding protein Gene OMIM 603167 BAD BBC2 BBC6 BCL2 antagonist of cell death protein MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ BCL2 binding component 6 BAD AFFYMETRIX 209364_at AFFYMETRIX 1861_at AFFYMETRIX g1683636_3p_s_at AFFYMETRIX Hs.287565.0.S1_3p_at AFFYMETRIX 232660_at CPATH 109 Pubmed 11733063 in vivo PSIMI MI:0493 PHYSIOL-LEFT-TO-RIGHT Phosphorylation of ITGB4 by MET.Met Activation Induces Tyrosine Phosphorylation of the beta4 Integrin, and promotes Shc and PI3K dependent pathways.Interaction between ITGB4 and MET occurs at the plasma membrane. P-MET-ITGB4 plasma membrane GO 0005886 CPATH 38 Phosphorylation phosphorylation reaction PSIMI MI:0217 Pubmed 11733063 PSIMI MI:0170 phosphorylation site plasma membrane GO 0005886 NOT-SPONTANEOUS in vivo PSIMI MI:0493 CPATH 39 Pubmed 10811835 plasma membrane GO 0005886 Interaction between CD151 and ITGA6. in vivo PSIMI MI:0493 CD151-ITGA6 plasma membrane GO 0005886 CD151-ITGA6 direct interaction PSIMI MI:0407 CPATH 28 Pubmed 12482924 MI:0018 PSIMI two hybrid in vitro MI:0492 PSIMI plasma membrane GO 0005886 BPAG2-PLEC1 Interaction between BPAG2 and PLEC1 BPAG2-PLEC1 direct interaction PSIMI MI:0407 CPATH 84 refseq NP_958782 Intermediate filament binding protein, 500kD Plectin 1 PLEC1 Pubmed 10525545 PCN Homo sapiens 9606 taxon EBSO PLEC1 EBS1 8633055 Pubmed OMIM 601282 Gene 03180 HPRD HD1 MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA PLEC1 PLTN AFFYMETRIX 1563654_at AFFYMETRIX 38022_s_at AFFYMETRIX 1563654_3p_at AFFYMETRIX 38021_at AFFYMETRIX Hs.79706.2.S1_3p_a_at AFFYMETRIX g4505876_3p_s_at AFFYMETRIX 201373_3p_at AFFYMETRIX 216971_s_at AFFYMETRIX 201373_at CPATH 98 PHYSIOL-LEFT-TO-RIGHT GO 0005634 nucleus Phosphorylation of 4EBP1 by FRAP1.Alpha6Beta4 integrin activates the PI-3K-Akt pathway and, consequently, the rapamycin-sensitive kinase mTOR(FRAP1)which then phosphorylates and inactivates 4E-BP1 (a translational repressor) and promotes VEGF translation. P-FRAP1-4EBP1 12105188 Pubmed in vivo PSIMI MI:0493 CPATH 57 FRAP2 Gene OMIM 601231 03134 HPRD 12105188 Pubmed FRAP1 Homo sapiens 9606 taxon mTOR FRAP 11114166 Pubmed FK506-binding protein 12 rapamycin complex associated protein 1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW refseq NP_004949 FRAP1 Mammalian target of rapamycin RAFT1 FRAP1 AFFYMETRIX 202288_at AFFYMETRIX 215381_at AFFYMETRIX Hs.288569.0.S1_3p_x_at AFFYMETRIX 40139_at AFFYMETRIX g3282238_3p_at AFFYMETRIX 267_at AFFYMETRIX 215381_3p_at CPATH 108 Phosphorylation 14579272 Pubmed NOT-SPONTANEOUS PSIMI MI:0170 phosphorylation site plasma membrane GO 0005886 in vitro MI:0492 PSIMI phosphorylation reaction PSIMI MI:0217 CPATH 37 OMIM Gene 159430 MASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKVPWLKPGRSPLPSHARSQPGLCNMYKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR MBP refseq NP_002376 MBP Myelin A1 protein Homo sapiens 9606 taxon Pubmed 9136767 Myelin membrane encephalitogenic protein HPRD 01158 MBP Myelin basic protein AFFYMETRIX g187408_3p_at AFFYMETRIX g4505122_3p_a_at AFFYMETRIX 209072_at AFFYMETRIX Hs2.69547.4.S1_3p_s_at AFFYMETRIX 207323_s_at AFFYMETRIX 35817_at AFFYMETRIX 1554544_a_at AFFYMETRIX 236324_at AFFYMETRIX Hs.32149.0.A1_3p_at CPATH 102 Pubmed 12867433 plasma membrane GO 0005886 ITGB4-ITGA6 Interaction between ITGB4 and ITGA6. 11438664 Pubmed in vivo PSIMI MI:0493 9660880 Pubmed direct interaction PSIMI MI:0407 11438664 Pubmed ITGB4-ITGA6 Pubmed 12867433 CPATH 51 direct interaction PSIMI MI:0407 plasma membrane GO 0005886 GO 0005737 cytoplasm Pubmed 12919677 in vivo PSIMI MI:0493 in vitro MI:0492 PSIMI MI:0018 PSIMI two hybrid Interaction between MST1R and 14-3-3-epsilon MST1R-YWHAE MST1R-YWHAE CPATH 8 14-3-3-epsilon KCIP-1 Homo sapiens 9606 taxon YWHAE Tyrpsine 3-monoogenase/typtophan 5-monoxygenase activation protein, epsilon isoform MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ 14-3-3 epsilon Mitochondrial import stimulation factor L subunit 14-3-3E YWHAE Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide NP_006752 refseq Pubmed 11864996 14-3-3-epsilon Pubmed 12919677 Gene 605066 OMIM Protein kinase C inhibitor protein-1 MDCR MDS HPRD 05457 AFFYMETRIX 1011_s_at AFFYMETRIX Hs.79474.4.A1_3p_at AFFYMETRIX 210317_s_at AFFYMETRIX 210996_s_at AFFYMETRIX 213655_at AFFYMETRIX g4096984_3p_a_at AFFYMETRIX g984318_3p_a_at CPATH 116 Interaction between Alpha6Beta4 and NTN1 direct interaction PSIMI MI:0407 Alpha6Beta4-NTN1 0008372 GO cellular component unknown plasma membrane GO 0005886 in vivo PSIMI MI:0493 in vitro MI:0492 PSIMI Pubmed 14602071 Alpha6Beta4-NTN1 CPATH 23 8999943 Pubmed plasma membrane GO 0005886 ITGA6-LAMR1 in vivo PSIMI MI:0493 ITGA6-LAMR1 GO 0005737 cytoplasm Interaction between ITGA6 and LAMR1 direct interaction PSIMI MI:0407 CPATH 40 MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS Homo sapiens 9606 taxon LAMR1 p40 Laminin receptor, 67-KD LAMR1 LAMBR RPSA 150370 OMIM Gene LAMR1 67kD, Ribosomal protein SA Laminin receptor 1 01038 HPRD 8985115 Pubmed LRP 67LR 8999943 Pubmed refseq NP_002286 37LRP AFFYMETRIX Hs.181357.2.A1_3p_x_at AFFYMETRIX 216806_at AFFYMETRIX 256_s_at AFFYMETRIX Hs.307102.0.S1_3p_at AFFYMETRIX 213801_x_at AFFYMETRIX Hs.307102.0.S1_3p_x_at CPATH 121 P-SRC-PTK2 Phosphorylation of PTK2 by SRC. GO 0005737 cytoplasm PHYSIOL-LEFT-TO-RIGHT Pubmed 12110680 in vitro MI:0492 PSIMI CPATH 72 c-Src 01819 HPRD Homo sapiens 9606 taxon Avian sarcoma virus protein refseq NP_005408 190090 OMIM Gene Pubmed 12110680 c-Src ASV SRC Pubmed 9560226 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL SRC AFFYMETRIX 213324_at AFFYMETRIX 221281_at AFFYMETRIX 1565080_at AFFYMETRIX Hs2.383588.2.A1_3p_at AFFYMETRIX Hs.198298.1.A1_3p_at AFFYMETRIX Hs.198298.0.S1_3p_at AFFYMETRIX Hs2.383588.1.A1_3p_s_at AFFYMETRIX 1558210_at AFFYMETRIX 1558211_s_at AFFYMETRIX Hs2.383588.2.A1_3p_x_at AFFYMETRIX 38904_at AFFYMETRIX 1938_at AFFYMETRIX 221284_s_at AFFYMETRIX 1565082_x_at AFFYMETRIX g4885608_3p_a_at CPATH 141 Interaction between ITGB4 and laminin5 plasma membrane GO 0005886 ITGB4-Laminin5 direct interaction PSIMI MI:0407 Pubmed 12867433 in vitro MI:0492 PSIMI ITGB4-Laminin5 CPATH 35 plasma membrane GO 0005886 GO 0005737 cytoplasm 0008372 GO cellular component unknown PIK3R3-Human_PIK3CA-Human_PIK3CB-Human_PIK3CD-Human_PIK3CG-Human Homo sapiens 9606 taxon CPATH 137 HPRD 04161 PIK3CD p110-delta OMIM 602839 Gene Homo sapiens 9606 taxon MPPGVDCPMEFWTKEENQRVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSAPKAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWRPELLWMRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAPDALPAVSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLERALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGTVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDLVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFREKFNEALREGWKTKVNWLAHNVSKDNRQ uniprot AAB53966 12147247 Pubmed PIK3CD Phosphatidylinositol 3 kinase, catalytic subunit, delta PIK3CD Pubmed 10973965 CPATH 94 refseq NP_006209 PIK3CA Pubmed 10213474 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPHVESSPELPKHIYNKLDRGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLKMMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINRALRIKILCATYVNLNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQERKDETQKVQMKFLVEQMRRPDFMDALQGLLSPLNPAHQLGNLRLKECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN p110-alpha Homo sapiens 9606 taxon 171834 OMIM Gene HPRD 01382 PIK3CA Pubmed 10973965 PI3-kinase, p110, subunit alpha PIK3CA AFFYMETRIX 40704_at AFFYMETRIX g5453891_3p_at AFFYMETRIX 204369_at CPATH 96 Pubmed 10973965 OMIM 601232 Gene refseq NP_002640 PIK3CG PIK3CG PI3K gamma MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA Homo sapiens 9606 taxon PIK3CG p110-gamma PI3-kinase p110 subunit gamma 03135 HPRD 11416136 Pubmed AFFYMETRIX g4505802_3p_at AFFYMETRIX 206370_at AFFYMETRIX 206369_s_at AFFYMETRIX g12620870_3p_a_at AFFYMETRIX g4505802_3p_x_at AFFYMETRIX 36287_at CPATH 92 602925 OMIM Gene refseq NP_006210 PIK3CB Homo sapiens 9606 taxon p110-beta PI3Kbeta 04234 HPRD MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS PIK3CB PIK3CB Pubmed 10973965 PI3K AFFYMETRIX 217620_s_at AFFYMETRIX 212688_at AFFYMETRIX Hs.181033.0.A1_3p_s_at AFFYMETRIX 31699_at AFFYMETRIX Hs.181033.0.A1_3p_at AFFYMETRIX Hs.239818.0.A2_3p_at CPATH 95 Phosphatidylinositol 3-kinase, regulatory gamma subunit p55PIK HPRD 05831 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDAAENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 606076 Gene OMIM PIK3R3 PIK3R3 PIK3R3 Pubmed 10973965 Homo sapiens 9606 taxon refseq NP_003620 p55 gamma AFFYMETRIX g3046405_3p_a_at AFFYMETRIX 37961_at AFFYMETRIX 34479_at AFFYMETRIX Hs.88051.0.S2_3p_at AFFYMETRIX 211580_s_at AFFYMETRIX 322_at AFFYMETRIX 202743_at CPATH 93 9374518 Pubmed in vivo PSIMI MI:0493 MI:0018 PSIMI two hybrid ITGB4-ITGB4BP ITGB4-ITGB4BP Molecular Association between ITGB4 and ITGB4BP. GO 0005737 cytoplasm direct interaction PSIMI MI:0407 plasma membrane GO 0005886 CPATH 49 GO 0005737 cytoplasm Pubmed 12919677 Interaction between MST1R and 14-3-3-eta MST1R-YWHAH in vitro MI:0492 PSIMI in vivo PSIMI MI:0493 MI:0018 PSIMI two hybrid direct interaction PSIMI MI:0407 plasma membrane GO 0005886 MST1R-YWHAH CPATH 54 Protein AS1 MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN YWHAH 113508 Gene OMIM Pubmed 12919677 YWHAH 14-3-3-eta 00215 HPRD Homo sapiens 9606 taxon Brain protein 14-3-3, eta isoform 14-3-3-eta Tyrosine 3-monooxygenase/Tryptophan 5-monooxygenase activation protein 1 YWHA1 Pubmed 11864996 refseq NP_003396 AFFYMETRIX 1424_s_at AFFYMETRIX g4507950_3p_at AFFYMETRIX Hs.226755.0.A1_3p_at AFFYMETRIX Hs.226755.1.A1_3p_at AFFYMETRIX 201020_at AFFYMETRIX 242325_at AFFYMETRIX 236559_at CPATH 130 12105188 Pubmed in vitro MI:0492 PSIMI GO 0005737 cytoplasm GO 0005634 nucleus Interaction of 4EBP1 and EIF4EPhosphorylation of 4EBP1 disrupts binding of EIF4E. 4EBP1-EIF4E direct interaction PSIMI MI:0407 4EBP1-EIF4E CPATH 71 Homo sapiens 9606 taxon Eukaryotic translation initiation factor 4E EIF4E Messenger RNA cap binding protein EIF4E MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 00591 HPRD 12105188 Pubmed EIF4E EIF4EL1 133440 OMIM Gene refseq NP_001959 EIF4E 10648556 Pubmed Eukaryotic translation initiation factor 4E like 1 AFFYMETRIX 201436_at AFFYMETRIX 201437_s_at AFFYMETRIX Hs.79306.0.A3_3p_x_at AFFYMETRIX 37752_at AFFYMETRIX 201436_3p_at AFFYMETRIX Hs.79306.0.A3_3p_at AFFYMETRIX 201435_s_at AFFYMETRIX g4503534_3p_a_at AFFYMETRIX Hs.98903.0.A1_3p_at AFFYMETRIX 237718_at AFFYMETRIX Hs.79306.0.A1_3p_a_at AFFYMETRIX g4503534_3p_x_at CPATH 104 direct interaction PSIMI MI:0407 Interaction between Alpha6Beta4 and laminin5 7721947 Pubmed plasma membrane GO 0005886 8143784 Pubmed Alpha6Beta4-Laminin5 in vitro MI:0492 PSIMI 8143784 Pubmed Alpha6Beta4-Laminin5 CPATH 22 PIK3R2-Human_PIK3R3-Human_PIK3CA-Human_PIK3CB-Human_PIK3CD-Human_PIK3CG-Human 0008372 GO cellular component unknown Homo sapiens 9606 taxon GO 0005737 cytoplasm plasma membrane GO 0005886 CPATH 132 MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR PIK3R2 PIK3R2 Phosphatidylinositol 3-kinase p85, beta subunit PIK3R2 HPRD 04404 p85 beta Pubmed 10973965 refseq NP_005018 Phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 Homo sapiens 9606 taxon 603157 Gene OMIM AFFYMETRIX Hs.211586.1.A1_3p_at AFFYMETRIX 229392_s_at AFFYMETRIX 207105_s_at AFFYMETRIX 34197_at AFFYMETRIX g4826907_3p_a_at AFFYMETRIX 388_at CPATH 97 11438664 Pubmed plasma membrane GO 0005886 PI3K-IRS1 in vivo PSIMI MI:0493 in vitro MI:0492 PSIMI PI3K-IRS1 Intercation of PI3K with IRS1 direct interaction PSIMI MI:0407 CPATH 53 plasma membrane GO 0005886 Alpha6Beta4-Laminin1 Alpha6Beta4-Laminin1 7721947 Pubmed direct interaction PSIMI MI:0407