ID (Pathway) from Homo sapiens
| Data Source: |
The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) |
| Availability: |
Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) |
| Comment: |
Id Proteins are members of the basic HLH(helix-loop-helix ) family of transcription factors but lack a DNA binding domain. The Id family of proteins comprises of 4 members designated Id1-Id4.They have been demonstrated to bind the ubiquitously expressed bHLH E-proteins or cell lineage-restricted bHLH transcription factors, leading to inhibition of lineage-specific gene expression and differentiation.Hence, the name Id refers to both inhibition of differentiation and inhibition of DNA binding.Id proteins have been implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. |
| View Expression Data on this Pathway |
Contains the Following Molecules (Showing 1 - 20 of 28) [display all]Contains the Following Interactions / Pathways (Showing 1 - 20 of 59) [display all]
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Biochemical Reaction(s)
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ID3 → ID3 (Phosphorylated) |
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ID2 → ID2 (Phosphorylated) |
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Catalysis Reaction(s)
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CDK2 activates [ID2 → ID2 (Phosphorylated)] |
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CDK2 activates [ID3 → ID3 (Phosphorylated)] |
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Physical Interaction(s)
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MYF5, ID1 |
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ID4, HES1 |
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ID2 |
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ID3, MYF6 |
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CCNA2, CDK2 |
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MYOD1, ID2 |
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HES1, ID1 |
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P204, ID1 |
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PSMD4, ID1 |
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ID2 |
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ID2, ADD1 |
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TCF3, ID1 |
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ID3, MYOG |
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ID2, RB |
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ID3 |
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HES1, ID3 |
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