EGFR1 (Pathway) from Homo sapiens
| Data Source: |
The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) |
| Availability: |
Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) |
| Comment: |
The Epidermal growth factor (EGF) signals through the epidermal growth factor (EGF) receptor (EGFR) family composed of four receptor tyrosine kinases (RTKs) designated EGFR, ErbB2 (also known as HER2 or neu), ErbB3 (HER3), and ErbB4 (HER4).In EGFR1 pathway, it includes interactions of EGF-EGFR only.Binding of EGF to the extracellular domain of these RTKs leads to receptor dimerization, activation of the intrinsic protein tyrosine kinase (PTK) activity, tyrosine autophosphorylation, and recruitment of various signaling proteins to the receptor. .Tyrosine phosphorylation of the EGFR leads to the recruitment of various signaling proteins, including the adaptor proteins Grb2 , Nck, phospholipase C gamma , Shc and other molecules. .The EGF receptor activates RAS and the MAP kinase pathways, ultimately causing phosphorylation of transcription factors such as c-Fos, c-Jun, ELK-1 . The STAT transcription factors are also activated by JAK kinases in response to EGF. .This pathway is involved in the regulation of a wide spectrum of biological processes including cell proliferation, apoptosis, cell cycle etc. |
| View Expression Data on this Pathway |
Contains the Following Molecules (Showing 1 - 20 of 177) [display all]Contains the Following Interactions / Pathways (Showing 1 - 20 of 475) [display all]
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