NOTCH (Pathway) from Homo sapiens
| Data Source: |
The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) |
| Availability: |
Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) |
| Comment: |
Notch is a cell-surface receptor that is activated by contact with membrane-bound ligands on neighboring cells. Extracellular regions of the Notch receptors (Notch1, Notch2, Notch3, Notch4) interact with ligands such as Dll1, Dll4, JAG1 and JAG2 to activate the Notch cascade. Interaction of Notch with its ligands triggers proteolytic processing of Notch, first by a metalloproteinase, and then by the gamma secretase complex (including presenilins). The cytoplasmic domain of Notch is released from the plasma membrane by proteolysis, and it then travels to the nucleus. In the nucleus, Notch interacts with CBF-1, CBF-3,MAML1, MAMl2, MAML3, FBXW7 to regulate the transcription of downstream genes. HES and HERP family proteins are the primary effectors of the Notch signaling pathway. Notch pathway controls various celular processes such as differentiation, apoptosis, transport, cell cycle and development. |
| View Expression Data on this Pathway |
Contains the Following Molecules (Showing 1 - 20 of 79) [display all]Contains the Following Interactions / Pathways (Showing 1 - 20 of 167) [display all]
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