Hedgehog (Pathway) from Homo sapiens
| Data Source: |
The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) |
| Availability: |
Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) |
| Comment: |
Hedgehogs are secreted proteins namely Sonic(SHH),Desert(DHH),Indian(IHH) found in mammals. After secretion, the diffusion of all three Hh ligands is limited to binding to transmembrane receptors such as HIP1,PATCHED1 (PTCH1),and PATCHED2 (PTCH2). In absence of ligand, Patched receptors block the function of another transmembrane protein, Smoothened (SMO) and this inhibition is relieved following ligand binding. SMO becomes active and intiates signalling cascade that results in the activation of GLI transcription factors which translocate to nucleus upon ligand binding and control target genes expression. Hh signalling regulates transcription of genes such as HHIP, PTCH, CCND2, CCNE1 and FOXG1A that are important for various cellular processes. Hedgehog pathway is essential for cell cycle regulation and embryogenesis. |
| View Expression Data on this Pathway |
Contains the Following Molecules (Showing 1 - 20 of 21) [display all]Contains the Following Interactions / Pathways (Showing 1 - 20 of 38) [display all]
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Biochemical Reaction(s)
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GLI1 → GLI1 (Phosphorylated) |
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Catalysis Reaction(s)
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DYRK1A activates [GLI1 → GLI1 (Phosphorylated)] |
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Physical Interaction(s)
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SAP18, SUFU |
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SHH, PTCH2 |
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GLI3, STK36 |
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GAS1, SHH |
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STK36, GLI2 |
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SKI, GLI3 |
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PTCH, CCNB1 |
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STK36, GLI1 |
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IHH, PTCH2 |
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PTCH, SMOH |
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HHIP, DHH |
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STK36, SUFU |
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PTCH, SHH |
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IHH, HHIP |
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IHH, PTCH |
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DYRK1A, GLI1 |
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CDC2, PTCH |
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GLI3, SUFU |
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