Wnt (Pathway) from Homo sapiens
| Data Source: |
The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) |
| Availability: |
Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) |
| Comment: |
WNT family members are secreted glycoproteins which bind to Frizzleds and LRPs, the cell surface receptors as well as with other downstream signaling components, like DVL, FRATs, casein kinases, AXINs etc. Under WNT stimulation, there are three sub pathways that have been reported such as Beta-catenin, Planar cell polarity and Calcium dependent. Canonical WNT/Beta-catenin pathway (WNT/Beta-catenin): Axin and APC bind to both beta-catenin and GSK3, to facilitate phosphorylation of beta-catenin by GSK-3beta. Phosphorylated beta-catenin is then degraded in proteasomes by the ubiquitination machinery (PMID: 15203747). Unphosphorylated beta-catenin first accumulates in the cytoplasm and then translocates to the nucleus where it associates with other transcription factors such as TCF3, TCF4 and LEF1 and regulate the expression of different target genes such as CDH1, CCND1, DKK1, JUN, MYC, FRA1, BTRC, CDX1. Non-canonical planar cell polarity pathway: WNT11 and WNT5A activate the WNT/JNK pathway which regulate planar cell polarity pathway. FZDs and DVLs are important components of this pathway. WNT/calcium signaling pathway: WNTs, FZDs and DVL2 activate calcium sensitive enzymes like PKCs and CAM kinase II to regulate cellular processes like cell migration, cell development and differentiation (PMID: 14766423). FRPs and DKKs are known to antagonize WNT signaling pathway.In general, activation of WNT pathway control various cellular processes like proliferation, development, adhesion, cell cycle, sex differentiation, migration, differentiation, polarity and apoptosis. |
| View Expression Data on this Pathway |
Contains the Following Molecules (Showing 1 - 20 of 105) [display all]Contains the Following Interactions / Pathways (Showing 1 - 20 of 223) [display all]
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