Alpha6Beta4Integrin (Pathway) from Homo sapiens
| Data Source: |
The Cancer Cell Map at Memorial Sloan-Kettering Cancer Center (http://cancer.cellmap.org) |
| Availability: |
Freely available from The Cancer Cell Map (created by Memorial Sloan-Kettering Cancer Center and the Institute of Bioinformatics) under the Creative Commons license (http://creativecommons.org/licenses/by/2.5/) |
| Comment: |
The integrins are cell membrane receptors composed of alpha and beta subunits. There are about 18 alpha subunits and 8 beta subunits.Integrins alpha6 and beta 4 heterodimerises to form the active receptor complex. Alpha6Beta4 are mainly involved with hemidesmosomes formation, cell adhesion and cell attachments. Many cytoskeletal proteins like keratins and Bullous pemphigoid antigen (BPAG) are associated with Alpha6beta4.They also associate with other receptors like Epidermal Growth factor receptor(EGFR), macrophage stimulating factor receptors. The vital ligands are Laminins, Kalinins. Various kinases (like MEKs, ERKs, PKCs, YES, FYN) and adapter molecules like (GRBs) are involved in this pathway. Alpha6beta4 modulate processes as diverse as cell proliferation, differentiation, apoptosis, migration and tissue morphogenesis. |
| View Expression Data on this Pathway |
Contains the Following Molecules (Showing 1 - 20 of 55) [display all]Contains the Following Interactions / Pathways (Showing 1 - 20 of 85) [display all]
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